Figure 6.

Twenty-three hour water-deprived B6 mice show no effects of AngII on gustatory nerve responses to NaCl (amiloride-sensitive component) and sweeteners. A, Typical examples of CT nerve responses of 23 h water-deprived B6 mice 30 min after intraperitoneal injection of 1000 ng/kg bw of AngII (lower traces) versus vehicle-injected controls (upper traces). B, CT nerve responses (normalized to 100 mm NH₄Cl) of water-deprived B6 mice stimulated by salty [NaCl, 300 mm NaCl; Na + Ami, 300 mm NaCl + 30 μm amiloride; AS, amiloride-sensitive component (obtained by subtracting Na + Ami from NaCl); KCl, 100 mm KCl], sweet (Glc, 500 mm glucose; Suc, 500 mm sucrose; Sac, 20 mm saccharin; SC, 1 mm SC45647), sour (HCl, 10 mm HCl), umami (MSG, 100 mm monosodium glutamate + 30 Ami), and bitter (QHCl, 20 mm quinine-HCl) compounds 10–30 min after administration of vehicle as control (black bars) or 1000 ng /kg bw of AngII (red bars) (n = 6 each). Significant differences were not detected from control (p > 0.1, paired t test). All data are presented as the mean ± SEM.