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. 2013 Apr 10;33(15):6691–6704. doi: 10.1523/JNEUROSCI.0032-12.2013

Figure 1.

Figure 1.

Decrease in newborn cell proliferation at PW6 by MAM treatment and rescue at PW10. A, Experimental design for MAM treatment and behavioral tests. B, ANOVA analysis revealed a significant decrease in newborn cell numbers in a dose-dependent manner immediately after 2 week MAM treatment (F(3,28) = 15.58428, p < 0.0001, n = 8 mice for each group). C, Rescue of new cell proliferation was observed 4 weeks later at PW10 (F(2,21) = 1.88832, p = 0.17614 for 1 mg/kg and 3 mg/kg MAM vs saline control), except for the highest dose of MAM treatment (F(1,14) = 30.96936, p = 0.00007 for 5 mg/kg MAM vs saline control, n = 8 mice for each group). D, MAM treatment induced a dose-dependent change in body weight (repeated ANOVA: F(3,44) = 116.77, p < 0.001; 1-way ANOVA at the last day of MAM treatment: F(1,22) = 0.02353, p = 0.87949 for 1 mg/kg MAM vs saline control; F(1,22) = 26.76762, p = 0.00003 for 3 mg/kg MAM vs saline control; F(1,22) = 106.61121, p < 0.0001, n = 12 mice for each group). E, Body weights were recovered by PW10 (F(2,21) = 2.12923, p = 0.14389 at 1 mg/kg and 3 mg/kg MAM vs saline control, n = 8 mice for each group), except for the highest dose of MAM (F(1,14) = 13.92006, p = 0.00224 for 5 mg/kg MAM vs saline control, n = 8 mice for each group). *p < 0.05; **p < 0.01.