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. 2013 Apr 10;33(15):6691–6704. doi: 10.1523/JNEUROSCI.0032-12.2013

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Copyright © 2013 the authors 0270-6474/13/336691-14$15.00/0

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Figure 7. — Behavioral defects in MAM mice were rescued by an EE application that included PW4–PW6. A, Experimental design for MAM treatment, EE application during PW4–PW10, and PPI testing. B, MAM group displayed PPI deficits, which were rescued by an EE application during PW4–PW10 (2-way ANOVA with group treatment and prepulse intensity: F_(9,44) = 0.999, p = 0.455; 1-way ANOVA with blue bar, PP3: F_(1,10) = 5.35715, p = 0.04934; PP6: F_(1,10) = 5.52419, p = 0.04666; PP12: F_(1,10) = 6.53438, p = 0.03384 for MAM vs saline; hatched blue bar, PP3: F_(1,10) = 6.01467, p = 0.03978; PP6: F_(1,10) = 13.71342, p = 0.00602; PP12: F_(1,10) = 13.79835, p = 0.00592 for MAM plus EE vs MAM, n = 6 for each group). C, The spontaneous hyperactivity in the MAM group was rescued by EE application during PW4–PW10 (first minutes: F_(1,10) = 8.44982, p = 0.01565 for MAM vs saline; F_(1,10) = 19.25921, p = 0.00136 for MAM plus EE vs MAM; second 5 min: F_(1,10) = 26.81883, p = 0.00023 for MAM vs saline; F_(1,10) = 23.71114, p = 0.00039 for MAM plus EE vs MAM, n = 6 for each group). D, Anxiety-like behaviors in the MAM group were also rescued by EE application (F_(1,10) = 6.33847, p = 0.03051 for MAM vs saline, F_(1,10) = 10.00856, p = 0.0101 for MAM plus EE vs MAM, n = 6 for each group). *p < 0.05; **p < 0.01. E, Experimental design for MAM treatment, EE application during PW6–PW10 and PPI testing. F, The MAM group displayed PPI deficits that were not rescued by an EE application during PW6–PW10 (2-way ANOVA with group treatment and prepulse intensity: F_(9,56) = 0.902, p = 0.53; 1-way ANOVA with blue bar, PP3: F_(1,10) = 5.03714, p = 0.04864; PP6: F_(1,10) = 10.97326, p = 0.00784; PP12: F_(1,10) = 7.63621, p = 0.02001 for MAM vs saline; hatched blue bar, PP3: F_(1,10) = 0.90189, p = 0.36466; PP6: F_(1,10) = 0.45422, p = 0.51561; PP12: F_(1,10) = 0.00407, p = 0.9504 for MAM vs saline, n = 6 for each group). G, The spontaneous hyperactivity in the MAM group was rescued by EE application during PW6–PW10 (first minutes: F_(1,10) = 6.17334, p = 0.03229 for MAM vs saline; F_(1,10) = 11.23893, p = 0.00733 for MAM plus EE vs MAM; second 5 min: F_(1,10) = 7.35725, p = 0.02184 for MAM vs saline; F_(1,10) = 7.53281, p = 0.02067 for MAM plus EE vs MAM, n = 6 mice for each group). H, Anxiety-like behaviors in the MAM group were also rescued by EE application (F_(1,10) = 5.25848, p = 0.04477 for MAM vs saline; F_(1,10) = 0.55739, p = 0.4725 for MAM plus EE vs MAM, n = 6 mice for each group). *p < 0.05; **p < 0.01.