Table 2.

Association of impaired neurogenesis and deficits in prepulse inhibition

Species (strain)	Treatment method	Treatment time	Neurogenesis	Test time point	PPI	References
Lewis rat	Polyinosinic-polycytidylic acid, 4 mg/kg, i.v.	Gestational day 15	Not mentioned	Adult offspring	↓	Cardon M et al., 2010
Sprague Dawley rat	MAM, 25 mg/kg, i.v.	Gestational day 17	Not mentioned	Adult female offspring	↓	Hazane F et al., 2009
Sprague Dawley rat	Ara-c, i.c.v	Adult	∼90% decrease at adult stage	4 d after injection	↓	Lau BW et al., 2009
Sprague Dawley rat	Corticosterone, s.c.	Adult	∼45% decrease at adult stage	2 weeks after injection	↓	Lau BW et al., 2009
Sprague Dawley rat	Paroxetine, i.p.	Adult	∼45% increase at adult stage	2 weeks after injection	Not significant	Lau BW et al., 2009
Sprague Dawley rat	Exercise	Adult	∼45% increase at adult stage	2 weeks after injection	Not significant	Lau BW et al., 2009
Sprague Dawley rat	Heterozygous Pax6 mutant	Not mentioned	∼30% and ∼40% decrease at 4 weeks and 12 weeks respectively	Not mentioned	Not mentioned	Maekawa M et al., 2005
Sprague Dawley rat	Heterozygous Pax6 mutant	Not mentioned	Not mentioned	12 weeks	↓	Maekawa M et al., 2009
Sprague Dawley rat	MAM, 10 mg/kg, i.p.	4∼5 weeks	∼25% decrease at 5 weeks	12 weeks	↓	Maekawa M et al., 2009
129/SvEv C57BL/6	Npas3−/− mice	12 weeks	∼85% decrease at 12 weeks	Not mentioned	Not mentioned	Brunskill EW et al., 2005
C57BL/6J mouse	Severe combined immune deficient model	Not mentioned	∼20% and ∼40% decrease at 4 weeks and 12 weeks respectively	12 weeks	↓	Cardon M et al., 2009
129/SvEv C57BL/6	Npas1−/−:Npas3−/− mice	Not mentioned	Not mentioned	17∼20 weeks	↓	Erbel-Sieler C et al., 2004
C57BL/6J mouse	X-irradiated	4 weeks	∼90% decrease at 4 weeks	12 weeks	↓	Hayashi H et al., 2008
C57BL/6J mouse	Enrichment environment	3∼11 weeks	∼65% increase at 12 weeks	12∼13 weeks	↑	Iso H et al., 2007
C57BL/6J mouse	Fabp7-null mice	Not mentioned	∼30% decrease at 4 weeks	Not mentioned	↓	Watanabe A et al., 2007