Figure 5.

Changes in evoked CBF, tpO₂, and CMRO₂ responses after CSD using stimulation at 4 Hz for 15 s. HET0016 treatment had no effect on any of the evoked parameters. A, Evoked CBF responses decreased after CSD with no difference between control and intervention groups (control = 10 rats, HET0016 = 8 rats). Responses returned toward control values over the next 2 h. B, Evoked tpO₂ responses also decreased after CSD but showed no recovery over the next 2 h and no differences between the control and intervention groups. C, Evoked CMRO₂ responses were larger after CSD in the control group compared with the group treated with HET0016. *p < 0.05 compared with pre-CSD values in the same group. Abscissa shows the time after CSD in minutes. Data are mean ± SEM.