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. 2013 Feb 6;33(6):2650–2660. doi: 10.1523/JNEUROSCI.2037-12.2013

Figure 6.

Figure 6.

Clathrin-mediated internalization of GABAARs underlies the expression of LTDGABA. a, b, Single experiments showing induction of LTDGABA in cells loaded with Pitstop2 control peptide (filled symbols) or Pitstop2 (open symbols). Insets, Averaged IPSCs before (black) and 25 min after (red) pairing. Calibration: 50 pA, 25 ms. c, Averaged LTD experiments with Pitstop2 control peptide (filled symbols) or Pitstop2 (open symbols). Pitstop2 blocks pairing-induced LTDGABA, whereas control peptide did not affect the induction of LTDGABA (control peptide cells, 76 ± 3% of pre-pairing values, F(5.9,17.88) = 10.149, p < 0.0001; Pitstop cells, 115 ± 5% of pre-pairing values, F(1.39,4.17) = 5.129, p = 0.080).