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. 2013 Feb 6;33(6):2481–2493. doi: 10.1523/JNEUROSCI.4440-12.2013

Figure 7.

Figure 7.

Expression of the microglial proliferation regulatory proteins in variant Creutzfeldt–Jakob disease and Alzheimer disease. A–C, Immunohistochemical analysis of the expression of IL34 (A), PU.1 (B), and C/EBPa (C) in the white and gray matter of the temporal cortex of vCJD and AD brains compared with age-matched controls (CTL; representative images). Quantification data expressed as mean ± SEM of the number of IL34+ (D), PU.1+ (E), or C/EBPa+ (F) cells per square millimeters. G, H, Immunohistochemical analysis of the expression of Ki67 (marker of proliferation, G) in microglial cells (Iba1+, G) and IL34 (H) in astrocytes (GFAP+, H) in the temporal cortex of vCJD brains. A–C, Nuclei are stained with H/E (blue). G, H, Fluorescent sections evaluated with confocal microscopy. *p < 0.05, **p < 0.01, ****p < 0.0001, expressed versus the correspondent age-matched control. Data were analyzed with a two-way ANOVA and a post hoc Tukey test (n = 9–10). Scale bars: A–C, G, H (in A, G, H), 100 μm.