Table 3.

Summary of Pearson Correlation Between Plasma Cabotegravir PK Parameters and Hepatic Function

PK Parameter	n	Hepatic Function Parameter	Pearson Correlation Coefficient	P
FU2H, %	14	Albumin concentration, g/L	−0.85	<.001
		Total Child‐Pugh score	0.61	.021
		Serum albumin score	0.91	<.001
		Serum bilirubin score	0.52	.058
		PT (INR)	0.60	.025
		Total bilirubin, µmol/L	0.42	.132
		α‐1 Acid glycoprotein, g/L	0.28	.337
		Total protein, g/L	−0.67	.009
FU24H, %	14	Albumin concentration, g/L	−0.63	.016
		Total Child‐Pugh score	0.53	.049
		Serum albumin score	0.60	.022
		Serum bilirubin score	0.33	.251
		PT (INR)	0.49	.073
		Total bilirubin, µmol/L	0.37	.188
		α‐1 Acid glycoprotein, g/L	−0.30	.304
		Total protein, g/L	−0.37	.195

Hepatic function parameters of total Child‐Pugh score, serum albumin, serum bilirubin, and PT (INR) were treated as continuous variables. Participants with normal hepatic function were considered to have a score of 0. FU2H, unbound fraction at 2 hours; FU24H, unbound fraction at 24 hours; INR, international normalized ratio; PT, prothrombin time.