. 2013 Feb 27;33(9):4055–4065. doi: 10.1523/JNEUROSCI.4428-12.2013

Table 1.

Volume changes

Region	Absolute volume (mean ±SD)
Region	Wild type (n = 10)	Itsn1^Gt/Gt (n = 14)	Itsn2^−/− (n = 15)	Itsn1^Gt/GtItsn2^−/− (n = 3)
Amygdala	12.70 ± 1.13	12.90 ± 0.57	12.64 ± 1.42	11.72 ± 0.47
Anterior commissure—Pars anterior	1.64 ± 0.25	1.19 ± 0.14^**	1.67 ± 0.16	0.99 ± 0.03^**
Anterior commissure—Pars posterior	0.51 ± 0.09	0.35 ± 0.06^**	0.54 ± 0.06	0.35 ± 0.02^**
Arbor vita of the cerebellum	13.25 ± 0.94	12.82 ± 1.56	12.66 ± 1.35	12.51 ± 0.93
Cerebellar cortex	53.04 ± 4.18	53.59 ± 3.32	50.90 ± 6.19	50.07 ± 2.89
Cerebellar peduncle—Inferior	0.82 ± 0.08	0.85 ± 0.16	0.81 ± 0.09	0.87 ± 0.17
Cerebellar peduncle—Middle	1.45 ± 0.11	1.47 ± 0.19	1.57 ± 0.13	1.38 ± 0.10
Cerebellar peduncle—Superior	0.99 ± 0.07	0.97 ± 0.10	0.99 ± 0.10	0.94 ± 0.07
Cerebral cortex—Entorhinal cortex	7.84 ± 0.81	7.76 ± 0.38	7.34 ± 1.06	6.92 ± 0.58
Cerebral cortex—Frontal lobe	38.30 ± 5.92	39.18 ± 1.95	38.36 ± 3.70	35.83 ± 2.11
Cerebral cortex—Occipital lobe	4.89 ± 0.56	4.99 ± 0.34	4.66 ± 0.55	4.73 ± 0.25
Cerebral cortex—Parietotemporal lobe	67.05 ± 7.51	65.01 ± 2.29	66.13 ± 6.45	59.42 ± 3.09
Cerebral peduncle	2.37 ± 0.17	1.97 ± 0.22 ^*	2.38 ± 0.23	1.96 ± 0.19 ^*
Colliculus—Inferior	5.18 ± 0.32	4.37 ± 0.35 ^**	5.18 ± 0.43	3.89 ± 0.26 ^**
Colliculus—Superior	8.04 ± 0.98	6.62 ± 0.50 ^**	7.90 ± 0.77	5.99 ± 0.22 ^**
Corpus callosum	18.84 ± 2.42	15.96 ± 1.24 ^**	19.56 ± 1.84	14.46 ± 0.95 ^**
Fimbria	3.35 ± 0.62	2.57 ± 0.20 ^**	3.43 ± 0.38	2.42 ± 0.17 ^**
Fornix	0.84 ± 0.07	0.91 ± 0.07	0.85 ± 0.10	0.92 ± 0.12
Globus pallidus	2.60 ± 0.39	2.14 ± 0.19 ^*	2.64 ± 0.24	2.02 ± 0.15 ^*
Hippocampus	19.59 ± 2.35	18.31 ± 0.90	18.75 ± 1.64	16.86 ± 0.72 ^*
Hypothalamus	9.56 ± 0.85	9.97 ± 0.59	9.52 ± 0.98	9.32 ± 0.39
Internal capsule	2.98 ± 0.42	2.64 ± 0.31	3.04 ± 0.30	2.44 ± 0.12 ^*
Medulla	25.71 ± 1.77	24.63 ± 2.34	23.95 ± 2.84	24.44 ± 2.95
Midbrain	13.15 ± 1.07	11.41 ± 0.80 ^**	12.97 ± 1.10	10.65 ± 0.29 ^**
Olfactory bulbs	26.13 ± 2.75	22.78 ± 1.66 ^**	25.90 ± 2.47	19.60 ± 0.38 ^**
Optic tract	1.78 ± 0.17	1.54 ± 0.18 ^*	1.75 ± 0.17	1.44 ± 0.13 ^*
Pons	16.99 ± 1.06	16.16 ± 1.27	16.49 ± 1.43	15.53 ± 0.45
Posterior commissure	0.15 ± 0.01	0.17 ± 0.02	0.15 ± 0.02	0.16 ± 0.01
Striatum	18.82 ± 3.42	16.28 ± 0.75 ^*	19.26 ± 1.92	13.67 ± 0.30 ^**
Thalamus	15.34 ± 2.23	14.44 ± 0.47	15.75 ± 1.32	12.82 ± 0.34 ^*

The absolute volume measurements in mm³ for each region of interest.

* indicates significance based on an FDR of <0.05 or ** <0.01 with respect to wild type.