Table 2.
Sensorimotor test battery, rotarod, and actimetry (mean scores ± SEM)
| Vehicle |
RO4938581 |
F(1,43) |
|||||
|---|---|---|---|---|---|---|---|
| CO | TS | CO | TS | Genotype | Treatment | Genotype × treatment | |
| Vision (score 0–4 × 3 trials) | 8.54 ± 0.57 | 8.23 ± 0.60 | 7.64 ± 0.47 | 7.67 ± 0.88 | 0.07, p = 0.79 | 1.18 p = 0.28 | 0.09, p = 0.75 |
| Auditory startle (score 0–3) | 1.31 ± 0.24 | 1.15 ± 0.19 | 1.00 ± 0.13 | 1.33 ± 0.17 | 0.22, p = 0.63 | 0.12, p = 0.72 | 1.38, p = 0.24 |
| Righting reflex (score 0–3) | 3.00 ± 0.00 | 3.00 ± 0.00 | 3.00 ± 0.00 | 3.00 ± 0.00 | |||
| Grip strength (score 0–3) | 2.00 ± 0.28 | 1.62 ± 0.24 | 1.55 ± 0.21 | 2.00 ± 0.24 | 0.00, p = 0.92 | 0.00, p = 0.92 | 3.71, p = 0.061 |
| Latency to fall wooden bar (s) | 19.8 ± 0.19 | 20.0 ± 0.0 | 20.00 ± 0.00 | 20.00 ± 0.00 | 0.75, p = 0.38 | 0.75, p = 0.38 | 0.75, p = 0.38 |
| Equilibrium aluminum bar (score 1–3) | 1.38 ± 0.43 | 2.31 ± 0.54 | 1.36 ± 0.45 | 1.00 ± 0.44 | 0.18, p = 0.67 | 1.48, p = 0.23 | 1.38, p = 0.24 |
| Latency to fall aluminum bar (s) | 14.03 ± 1.42 | 15.11 ± 1.55 | 14.73 ± 1.28 | 12.11 ± 2.07 | 0.37, p = 0.54 | 0.35, p = 0.55 | 1.05, p = 0.31 |
| Prehensile reflex (score 0–3) | 2.69 ± 0.17 | 2.92 ± 0.83 | 2.45 ± 0.31 | 2.67 ± 0.24 | 1.05, p = 0.31 | 1.31, p = 0.25 | 0.00, p = 0.97 |
| Traction capacity (score 0–3) | 2.31 ± 0.63 | 2.67 ± 0.62 | 1.82 ± 0.55 | 1.67 ± 0.62 | 0.02, p = 0.86 | 1.43, p = 0.23 | 0.16, p = 0.68 |
| Number of crossings coat hanging | 3.62 ± 0.96 | 3.67 ± 0.34 | 2.64 ± 0.43 | 3.33 ± 0.50 | 1.46, p = 0.23 | 2.56, p = 0.11 | 1.29, p = 0.26 |
| Latency arrival coat hanging (s) | 36.00 ± 5.62 | 32.42 ± 6.16 | 46.45 ± 5.79 | 35.44 ± 5.76 | 1.54, p = 0.22 | 1.28, p = 0.26 | 0.39, p = 0.53 |
| Rotarod (latency to fall, s) | |||||||
| 5 rpm | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | |||
| 25 rpm | 30.38 ± 5.85 | 39.92 ± 6.42 | 35.63 ± 7.47 | 34.33 ± 6.87 | 0.37, p = 0.54 | 0.00, p = 0.98 | 0.65, p = 0.42 |
| 50 rpm | 11.53 ± 3.67 | 11.76 ± 4.24 | 16.27 ± 3.99 | 10.22 ± 3.79 | 0.51, p = 0.47 | 1.55, p = 0.69 | 0.60, p = 0.44 |
| Acceleration cycle | 126.53 ± 15.55 | 158.38 ± 19.73 | 146.0 ± 17.56 | 145.55 ± 29.50 | 0.59, p = 0.44 | 0.02, p = 0.87 | 0.63, p = 0.43 |
| Actimetry (counts) | |||||||
| Dark | 107030.7 ± 18863.97 | 90334 ± 4202.28 | 90334.4 ± 21059.53 | 85212.86 ± 10008.14 | 1.16, p = 0.28 | 0.28, p = 0.59 | 0.83, p = 0.36 |
| Light | 19014.79 ± 4144.34 | 17850.61 ± 4202.28 | 21653.61 ± 2096.76 | 7732.37 ± 2048.73 | 0.52, p = 0.47 | 0.34, p = 0.56 | 0.07, p = 0.78 |