Table 3.
F values of RM-MANOVAs and post hoc analysis of each independent variable tested in the acquisition and cued sessions of the Morris water maze
| Session | Genotype | Treatment | Genotype × treatment | |
|---|---|---|---|---|
| Acquisition between sessions (S1–S8) | ||||
| RM-MANOVA genotype × treatment | F(7,38) = 18.71, p < 0.001 | F(1,38) = 26.91, p < 0.001 | F(1,38) = 10.68, p = 0.002 | F(1,38) = 10.83, p = 0.002 |
| Post hoc comparisons between each pair of learning curves | ||||
| Vehicle CO versus vehicle TS | F(1,23) = 46.14, p < 0.001 | |||
| RO4938581 CO versus RO4938581 TS | F(1,18) = 1.49, p = 0.24 | |||
| Vehicle TS versus RO4938581 TS | F(1,23) = 31.33, p < 0.001 | |||
| Vehicle CO versus RO4938581 CO | F(1,22) = 0.00, p = 0.98 | |||
| Acquisition (S9–S12) | ||||
| RM-MANOVA genotype × treatment | F(3,38) = 11.56, p = 0.002 | F(1,38) = 16.24, p < 0.001 | F(1,38) = 6.11, p = 0.020 | F(1,38) = 8.19, p = 0.008 |
| Post hoc comparisons between each pair of learning curves | ||||
| Vehicle CO versus vehicle TS | F(1,23) = 15.04, p = 0.002 | |||
| RO4938581 CO versus RO4938581 TS | F(1,18) = 1.98, p = 0.18 | |||
| Vehicle TS versus RO4938581 TS | F(1,23) = 7.65, p = 0.018 | |||
| Vehicle CO versus RO4938581 CO | F(1,22) = 0.16, p = 0.69 | |||
| Acquisition between trials | ||||
| RM-MANOVA genotype × trial | Trial: F(7,38) = 6.04, p < 0.001 | F(1,42) = 35.62, p < 0.001 | F(1,38) = 14.59, p < 0.001 | F = 14.78, p < 0.001 |
| Post hoc comparisons between each pair of learning curves | ||||
| Vehicle CO versus vehicle TS | F(1,23) = 50.67, p < 0.001 | |||
| RO4938581 CO versus RO4938581 TS | F(1,18) = 2.28, p = 0.14 | |||
| Vehicle TS versus RO4938581 TS | F(1,23) = 49.42, p < 0.001 | |||
| Vehicle CO versus RO4938581 CO | F(1,22) = 0.00, p = 0.99 | |||
| Thigmotaxis | ||||
| (All sessions) RM-MANOVA genotype × treatment | F(11,38) = 13.92, p < 0.001 | F(1,38) = 20.73, p < 0.001 | F(1,38) = 7.82, p = 0.009 | F(1,38) = 1.89, p = 0.18 |
| S1–S12 post hoc comparisons RM-MANOVA session × group | ||||
| TS vehicle: F(11,9) = 1.09, p = 0.37 | ||||
| CO vehicle: F(11,9) = 6.43, p < 0.001 | ||||
| TS RO4938581: F(11,12) = 5.62, p < 0.001 | ||||
| CO RO4938581: F(11,12) = 10.09, p < 0.001 | ||||
| Mean of cued sessions MANOVA genotype × treatment | F(1,38) = 9.82, p = 0.004 | F(1,38) = 2.43, p = 0.13 | F(1,38) = 2.14, p = 0.15 | |
| Probe trial | ||||
| n of crossings over platform | ||||
| MANOVA genotype × treatment | F(1,38) = 9.27, p = 0.005 | F(1,38) = 1.21, p = 0.29 | F(1,38) = 0.43, p = 0.51 | |
| n of entries in trained quadrant | ||||
| MANOVA genotype × treatment | F(1,38) = 10.41, p = 0.003 | F(1,38) = 5.24, p = 0.030 | F(1,38) = 0.69, p = 0.41 | |
| Percentage of time in quadrants | ||||
| MANOVA quadrant × genotype × treatment | Quadrant: F(3,37) = 13.56, p = 0.001 | F(1,38) = 2.91, p = 0.021 | F(1,38) = 10.92, p = 0.002 | F(1,38) = 1.10, p = 0.30 |
| Cues sessions | ||||
| Latency | ||||
| MANOVA genotype × treatment:treatment | F(1,38) = 3.93, p = 0.054 | F(1,38) = 8.58, p = 0.006 | F(1,38) = 5.76, p = 0.021 | |
| Speed | ||||
| MANOVA genotype × treatment | F(1,38) = 2.77, p = 0.10 | F(1,38) = 0.55, p = 0.46 | F(1,38) = 0.011, p = 0.91 |