Figure 3.

A, Locations of each electrode tip from 14 rats. All 112 recorded neurons were in the BA. B, Mean (±SEM) percentage of time spent freezing during each cue during early and late safety training for the 14 rats implanted with electrode arrays. Freezing to the Fear Cue was significantly higher than to any other cue during late safety training; *p < 0.001 as compared to mean freezing response to Reward Cue, Fear + Safety Cue, and Safety Cue during late safety training. C, Neurons were initially segregated into 3 classes. SAME denoted significant change in firing in the same direction to the Fear and Fear + Safety Cues (17.9% of recorded neurons). SELECTIVE denoted significant change in firing to the Fear or Fear + Safety Cues (38.4% of recorded neurons). NO CHANGE denoted no significant change in firing to the Fear or Fear + Safety Cues (43.7% of recorded neurons). Areas shaded in blue indicate the number of neurons showing a significant change in firing rate to the Reward Cue: 15 of 20 SAME neurons showed a significant change in firing in the same direction to the Reward Cue, Fear Cue, and Fear + Safety Cues; 22 of 43 SELECTIVE neurons and 12 of 49 NO CHANGE neurons were responsive to the Reward Cue. D, Neurons classified as SELECTIVE (n = 43) were further segregated. Safety denoted significant change in firing to only the Fear + Safety Cues and Safety Cue (23.3% of SELECTIVE neurons; n = 10). Safety and Reward denoted significant change in firing to the Fear + Safety and Safety and Reward Cues in the same direction (37.2% of SELECTIVE neurons; n = 16). Fear and Reward denoted significant change in firing to the Fear and Reward Cues in the same direction (13.9% of SELECTIVE neurons; n = 6). Fear denoted significant change to only the Fear Cue (25.6% of SELECTIVE neurons; n = 11).