Table 2.
Univariate analysis of clinicopathological risk factors for cervical nodal metastasis
| Variables | pN status | ||
|---|---|---|---|
| pN− (No. = 25) | pN+ (No. = 102) | P value | |
| Age (mean ± SD, years) | 59.4 ± 9.3 | 56.6 ± 9.1 | 0.18a |
| Sex, n (%) | |||
| Male | 25 (100.0) | 99 (97.0) | |
| Female | 0 (0.0) | 3 (3.0) | |
| Tumor site, n (%) | 0.1b | ||
| Hypopharynx | 15 (37.0) | 78 (76.0) | |
| Supraglottis | 10 (63.0) | 24 (24.0) | |
| pT classificationc, n (%) | 0.53b | ||
| T1 | 6 (24.0) | 14 (13.7) | |
| T2 | 13 (52.0) | 54 (53.0) | |
| T3 | 2 (8.0) | 16 (15.7) | |
| T4 | 4 (16.0) | 18 (17.6) | |
| Histological grading, n (%) | 0.26b | ||
| G1 | 2 (7.4) | 3 (3.0) | |
| G2 | 19 (77.8) | 70 (68.0) | |
| G3 | 4 (14.8) | 29 (29.0) | |
| Perineural invasion, n (%) | 1.000b | ||
| − | 22 (88.0) | 88 (86.3) | |
| + | 3 (12.0) | 14 (13.7) | |
| Lymphovascular invasion, n (%) | 0.02 b | ||
| − | 24 (92.6) | 77 (76.0) | |
| + | 1 (7.4) | 25 (24.0) | |
| Maximal tumor diameter (mean ± SD, mm) | 28.4 ± 13.0 | 31.0 ± 14.2 | 0.4a |
| Tumor depth (mean ± SD, mm) | 2.0 ± 1.3 | 7.4 ± 3.0 | <0.0001 a |
Abbreviations: CI, confidence interval; G1, well differentiated; G2, moderately differentiated; G3, poorly differentiated; OR, odds ratio; pN−, pathologically negative nodal metastasis; pN+, pathologically positive nodal metastasis; pT Classification, pathological tumor classification.
Bold values show P‐value<0.05.
a
Mann‐Whitney U test, P < 0.05.
b
Chi‐square test or Fisher's exact test, P < 0.05.
c
Tumor node metastasis staging system according to the American Joint Committee on Cancer (7th edition).