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. 2019 Jul 3;10:834. doi: 10.3389/fphys.2019.00834

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Copyright © 2019 Rougier, Essers, Gillet, Guichard, Sonntag, Shmerling and Abriel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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α1-Syntrophin staining in wild-type and knockdown α1-syntrophin knockdown cardiac sections and cardiomyocytes. (A) Immunostaining, using a pan-syntrophin antibody, of syntrophin in wild-type (Snta1 fl/fl^-) and cardiac-specific α1-syntrophin knockdown murine cardiomyocytes (mvm) (Snta1 fl/fl⁺). (B) Intensity quantification of syntrophin signal of four cells confirming the significant decrease of syntrophin in knockdown mice. (^∗p < 0.05). The number of cells is indicated in parentheses. (C) Duolink^® experiments showing a significant decrease in interaction (red dots) between Na_v1.5 and syntrophin in α1-syntrophin cardiac specific knockdown cardiomyocytes (Snta1 fl/fl⁺) compared to wild-type (Snta1 fl/fl^-).