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. 2019 Jul 3;10:834. doi: 10.3389/fphys.2019.00834

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Copyright © 2019 Rougier, Essers, Gillet, Guichard, Sonntag, Shmerling and Abriel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac action potentials measurements in in wild-type and knockdown α1-syntrophin knockdown cardiomyocytes. (A) Raw traces of cardiac action potential recorded in wild-type adult ventricular cardiomyocytes (Snta1 fl/fl^-) and α1-syntrophin cardiac specific knockdown cardiomyocytes (Sntα1 fl/fl⁺). (B) Upstroke velocity of cardiac action potential recorded in A from wild-type adult ventricular cardiomyocytes (Snta1 fl/fl^-) and α1-syntrophin cardiac specific knockdown cardiomyocytes (Sntα1 fl/fl⁺) showing the slowing of the upstroke velocity in action potential from knockdown cardiomyocytes. (C) Cardiac action potential parameters measured in wild-type (Snta1 fl/fl^-) and α1-syntrophin cardiac specific knockdown cardiomyocytes (Snta1 fl/fl⁺) reveal the significant decrease of the maximal upstroke velocity.