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. 2019 Jul 3;10:834. doi: 10.3389/fphys.2019.00834

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Copyright © 2019 Rougier, Essers, Gillet, Guichard, Sonntag, Shmerling and Abriel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacological characterization of the remaining sodium current at the lateral membrane of cardiomyocytes. (A) Plot chart showing the similarity in average sodium currents recorded at the lateral membrane of cardiomyocytes from ΔSIV and α1-syntrophin cardiac specific knockdown (Snta1 fl/fl⁺) cardiomyocytes using cell-attached configuration. (B) μ-conotoxin CnIIIC (CnIIIC) mediated the reduction in Na_v1.4 I_Na after 9 min of application in HEK-293 cell line. (C) Tetrodotoxin (TTX) and μ-conotoxin CnIIIC (CnIIIC) did not mediate any effect on I_Na recorded on the lateral membrane of ΔSIV cardiomyocytes using the cell-attached configuration (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001). The number of cells is indicated in parentheses.