. Author manuscript; available in PMC: 2019 Jul 10.

Published in final edited form as: Am Soc Clin Oncol Educ Book. 2017;37:575–585. doi: 10.14694/EDBK_175171

TABLE 1.

Clinical Examples of Geriatric Assessment Metrics

Domain	Metric Example	Clinical Conclusion
Function	SPPB²⁶	Impaired SPPB is associated with a twofold higher risk of death compared with those with a normal physical performance among populations with leukemia²⁷
	TUG	Poor mobility by TUG predicts early mortality among cancer populations
	Handgrip strength²⁸	Grip strength is an accurate and consistent predictor of all causes of mortality in middle-aged and elderly persons (RR, 0.89)²⁹
	Brief Fatigue Inventory³⁰	Fatigue strongly correlates with depression and is highly variable post-transplant³⁹
	ADL/IADL	Deficits in ADL, combined with age and comorbidities among patients with MM, resulted in notable survival differences in patients²¹
Psychiatric	HADS³¹	Psychiatric morbidity results in a significantly longer length of hospital stay and influences recovery post-transplant³²
Social	MOS Social Support Survey³¹	Social isolation and loneliness predict disease outcome and results in substantial impairment in psychologic and physical well-being³³
	MOS Social Support Survey³¹	Social support structure impacts clinical outcomes and quality of life post-transplant.^34,35
	3MS	Cognitive impairment demonstrates the greatest likelihood for mortality among older adults with leukemia²⁷
	3MS	Attention deficits persist for up to a year following myeloma transplant³⁶
Nutrition	MNA	Impaired nutritional status independently predicts early death in patients with newly diagnosed cancer at age 65 or older (OR, 2.77).
Comorbidities	Comorbidity calculator³⁸	HCT-CI predicts nonrelapse mortality and survival in MM^37,38

Abbreviations: SPPB, Short Physical Performance Battery; TUG, Timed Up and Go Test; ADL, activities of daily living; IADL, instrumental activities of daily living; HADS, Hospital Anxiety and Depression Scale; MOS, Medical Outcomes Study; 3MS, Modified Mini Mental State; MNA, Mini-Nutritional Assessment; RR, relative risk; MM, multiple myeloma; OR, odds ratio; HCT-CI, hematopoietic cell transplantation comorbidity index.