Table 1.

Comparison of AP-5 and RO effect on CA3 oscillations

	AP-5 (50 μm)			RO 25-6981 (5 μm)
	Septal		Temporal	Septal		Temporal
Waveform amplitude (mV)	0.11 ± 0.02 to 0.10 ± 0.02		0.22 ± 0.02 to 0.23 ± 0.03	0.12 ± 0.03 to 0.11 ± 0.03		0.31 ± 0.07 to 0.21 ± 0.07
		NS			NS
	NS		NS	NS		NS
Waveform rising time (ms)	114.7 ± 6.6 to 124.5 ± 11.8		136.1 ± 9.5 to 119.9 ± 8.4	136.7 ± 14.7 to 126.0 ± 15.1		116.7 ± 11.6 to 98.3 ± 8.5
		NS			NS
	NS		NS	NS		NS
Waveform decay time (ms)	96.5 ± 4.7 to 58.0 ± 3.1		154.8 ± 7.1 to 60.5 ± 4.7	84.0 ± 6.7 to 65.7 ± 5.7		145.2 ± 20.0 to 49.7 ± 4.3
		***			**
	↓↓↓ (38.0 ± 3.7%)		↓↓↓ (60.3 ± 2.7%)	↓ (20.4 ± 6.7%)		↓↓ (61.4 ± 6.2%)
Oscillation frequency (Hz)	1.96 ± 0.09 to 2.32 ± 0.16		1.91 ± 0.08 to 2.84 ± 0.14	2.22 ± 0.14 to 2.42 ± 0.27		1.88 ± 0.18 to 2.90 ± 0.17
		***			*
	↑↑ (17.9 ± 7.3%)		↑↑↑ (48.7 ± 4.1%)	NS		↑ (61.1 ± 21.8%)
Oscillation power (kμV2)	11.5 ± 2.1 to 6.4 ± 1.2		52.3 ± 8.8 to 41.6 ± 8.1
		NS			*
	↓↓ (38.8 ± 8.7%)		↓ (22.7 ± 9.6%)	NS		↓↓ (66.5 ± 17.1%)
	37.3 ± 2.8 to 27.2 ± 1.9		52.7 ± 2.3 to 37.3 ± 2.0	40.1 ± 7.2 to 33.5 ± 7.0		38.9 ± 3.6 to 27.8 ± 5.3
		NS			*
Oscillation strength	↓↓↓ (23.2 ± 6.5%)		↓↓↓ (28.3 ± 3.6%)	NS		↓ (28.9 ± 10.9%)

↑ indicates Significant increase; ↓, significant decrease. 1 arrow, p < 0.05; 2 arrows, p < 0.01; 3 arrows, p < 0.001. NS, not significant (p > 0.05, paired t test). AP-5, n = 17; RO, n = 6.

Significant differential effect septal versus temporal test:

*p < 0.05;

**p < 0.01;

***p < 0.001; NS, p > 0.05.