Figure 3.

Cellular disorganization at the ventricular zone in cortex lacking MPP3. A, C, At E16.5, control cortex progenitor cells at the ventricular zone are orderly organized. B, D, At E16.5, the Mpp3 cKO cortex showed cellular disorganization at the ventricular zone with cells detaching from the apical membrane. C and D are magnifications of the red boxes in A and B, respectively. E, F, As a control, MPP3 level and localization and cellular organization are indistinguishable between control (E) and Mpp3 cKO (F) in the third ventricle in which Cre recombinase is not expressed. G, H, Although there is cellular disorganization at the ventricular zone, the gross morphology, thickness, and organization of the layers is not different between Mpp3 cKO (H) and control (G). VZ, Ventricular zone; IZ, intermediate zone; CP, cortical plate. Scale bars, 20 μm.