Table 1. Characteristics of the 3 newborns with congenital Chagas infection.
Newborn 1 | Newborn 2 | Newborn 3 | |
---|---|---|---|
Maternal country | Bolivia | Bolivia | Bolivia |
Maternal age (years) | 25 | 26 | 38 |
Maternal disease status | Chronic | Chronic | Chronic |
Pregnancy | Singleton | Singleton | Singleton |
Gestational age (weeks) | 38+2 | 38+3 | 36+6 |
Mode of delivery | Vaginal—instrument assisted | Vaginal—spontaneous | Elective caesarian |
Gender | Female | Male | Male |
Clinical manifestations at birth | No | No | Yes |
PCR at birth | Positive | Positive | Positive |
PCR at 1 month of life | Positive | Positive | Positive |
Treatment | Benznidazole | Benznidazole | Benznidazole |
Treatment dose (mg/Kg/day) | 5 | 10 | 10 |
Treatment age of onset (days) | 45 | 30 | 15 |
Length of treatment (days) | 49 | 60 | 60 |
Secondary effects | Moderate neutropenia | - | - |
1st Serology (Age months /result) | 9 / Positive | 9 / Positive | 3 / Positive |
2nd Serology (Age months /result) | 12.9 / Negative | 15.6 / Negative | 3.8 / Positive |
3rd Serology (Age months /result) | - | - | 20.2 / Negative |
PCR post-treatment (Age months /result) | 12.9 / Negative | 9.9/ Negative | 3 / Negative |
Total blood samples obtained | 4 | 5 | 6 |