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. 2013 Jun 5;33(23):9626–9634. doi: 10.1523/JNEUROSCI.0482-13.2013

Figure 1.

Figure 1.

AβOs induce cognitive impairment in mice. A–C, Male Swiss mice received a single intracerebroventricular injection of 1, 10, or 50 pmol AβOs [or vehicle (VEH)] and were tested in the novel object recognition task 24 h (A), 7 d (B), or 14 d (C) after injection. Error bars represent means ± SEM of the time spent on the novel (black bars) or familiar (white bars) objects (n = 10 mice/group). *p < 0.05 (a statistically significant difference; one-sample Student's t test). D, Anti-AβOs (NU4) immunoreactivity in dot blots of hippocampal extracts from vehicle- or AβO-injected mice. Error bars represent means ± SEM (n = 3–5 mice/group). *p < 0.05 (statistically significant difference; Student's t test).