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. 2013 Jun 5;33(23):9626–9634. doi: 10.1523/JNEUROSCI.0482-13.2013

Figure 6.

Figure 6.

NMDA receptor blockade rescues HMW AβO-induced memory impairment. A, Mice were treated daily by gavage with 2, 10, or 20 mg/kg memantine (MEM) for 7 d before testing in the object recognition paradigm (n = 7–9 mice/group). B, Mice received a single intracerebroventricular injection of 10 pmol HMW AβOs and were treated daily by gavage with PBS or memantine (2 or 10 mg/kg) for 7 d before testing in the object recognition task (n = 8–10/group). C, Mice received a single intracerebroventricular injection of 10 pmol LMW AβOs and were treated daily by gavage with PBS or memantine (10 mg/kg) for 7 d before testing in the object recognition task (n = 8–10/group). D, Mice received a single intracerebroventricular injection of 10 pmol HMW AβOs and one intraperitoneal injection of PBS or MK-801 (0.1 mg/kg) 24 h before testing in the object recognition task (n = 8–10/group). Error bars represent means ± SEM of time spent on the novel (black bars) or familiar (white bars) objects. *p < 0.05 (statistically significant difference; one-sample Student's t test). VEH, Vehicle.