Figure 6.

Arctigenin reduced amyloid plaque formation in APP/PS1 AD mice. Mouse brain coronal paraffin sections were stained with thioflavine S and Congo red. A, Images of thioflavine S-stained amyloid plaques in hippocampus. B, Statistics of thioflavine S-stained amyloid plaques in hippocampus and cortex. C, Images of Congo red-stained amyloid plaques in cortex. D, Statistics of Congo red-stained amyloid plaques in hippocampus and cortex. T-V, Transgenic mice administrated with vehicle; NT-V, nontransgenic mice administrated with vehicle; T-ATG3, transgenic mice administrated with 3 mg/kg/d arctigenin. Values are means ± SE, *p < 0.05, ***p < 0.001 n = 10, compared with T-V. Scale bar, 100 μm.