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. 2013 Aug 7;33(32):13138–13149. doi: 10.1523/JNEUROSCI.4790-12.2013

Figure 8.

Figure 8.

Arctigenin enhanced autophagy with AMPK/Raptor pathway activation and AKT/mTOR pathway inhibition. For Western blot assay, the cortices were lysed in RIPA buffer. A, Arctigenin decreased ULK1 or P70S6K phosphorylation. B, Densitometry analysis of A. C, Arctigenin decreased AKT or mTOR phosphorylation. D, Densitometry analysis of C. E, Arctigenin increased AMPK or Raptor phosphorylation. F, Densitometry analysis of E. T-V, Transgenic mice administrated with vehicle; NT-V, nontransgenic mice administrated with vehicle; T-ATG3, transgenic mice administrated with 3 mg/kg/d arctigenin. Values are means ± SE, *p < 0.05, **p < 0.01, ***p < 0.001, n = 4, compared with T-V.