Table 1. Mutated genes in human HCC.
A total of 373 human HCC samples of the cBio cancer genomics portal were analyzed. The threshold for analysis was set for genes that were mutated in at least 8% of the samples.
| Missense Gene | Gene Name | % in human HCC | HepCell tumor | HepFrag tumor | iAST tumor |
|---|---|---|---|---|---|
| TP53 | Transformation related protein 53 | 30.8 | X | X | |
| TTN | Titin | 27.1 | |||
| CTNNB1 | Catenin beta 1 | 26 | |||
| MUC16 | Mucin 16 | 14.5 | |||
| ALB | Albumin | 11.5 | X | ||
| APOB | Apolipoprotein B | 10.5 | |||
| RYR2 | Ryanodine receptor 2, cardiac | 10.5 | X | X | |
| PCLO | Piccolo | 9.4 | X | X | X |
| LRP1B | Lipoprotein receptor-related protein 1B | 8.8 | |||
| CSMD3 | CUB and Sushi multiple domains 3 | 8.8 | X | X | |
| ARID1A | AT-rich interactive domain-containing protein 1A | 8.6 | |||
| ABCA13 | ATP Binding Cassette Subfamily A Member 13 | 8.6 | X | X | |
| CACNA1E | Calcium channel subunit alpha-1E | 8.3 | |||
| OBSCN | Obscurin | 8 | X | X | |
| RYR1 | Ryanodine receptor 1 | 8 |