Fig 6. Total water entropy (-TΔS) density distributions in the FXa binding site.
(A) GIST and (B) 3D-RISM with molecular reconstruction. Isosurfaces are shown for -2 (dark red), -1 (light red), 1 (light blue), and 2 (dark blue) kcal/mol/Å3. The FXa solvent accessible surface is shown in white. Numbers identify regions that are discussed in the text.