Table 4. OPLS analysis of metabolites with variable importance in projection for urinary protein levels.
A. 12 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Coniferyl alcohol-2TMS | 0.0864 ± 0.0678 | Glycine-3TMS | -0.1486 ± 0.0766 |
Proline-2TMS | -0.1460 ± 0.0796 | ||
Methionine-2TMS | -0.1445 ± 0.0439 | ||
Sorbose-meto-5TMS(1) | -0.1410 ± 0.0542 | ||
Thiodiglycolic acid-2TMS | -0.1392 ± 0.0551 | ||
Psicose-meto-5TMS(2) | -0.1387 ± 0.0411 | ||
B. 22 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Fucose-4TMS(1) | 0.1386 ± 0.0951 | Gluconic acid-6TMS | -0.1638 ± 0.0937 |
Galacturonic acid-5TMS(1) | 0.1029 ± 0.0949 | Glyceraldehyde-meto-2TMS(2) | -0.1426 ± 0.1055 |
Lysine-4TMS | -0.1389 ± 0.0643 | ||
Glyoxylic acid-meto-TMS | -0.1387 ± 0.1020 | ||
Isoleucine-2TMS | -0.1324 ± 0.1177 | ||
allo-Isoleucine-2TMS | -0.1324 ± 0.1177 | ||
4-Aminobutyric acid-2TMS | -0.1324 ± 0.1177 | ||
Thiodiglycolic acid-2TMS | -0.1283 ± 0.1037 | ||
C. 32 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Aconitic acid-3TMS | 0.1524 ± 0.0705 | Serine-3TMS | -0.1338 ± 0.1136 |
Myristic acid-TMS | 0.1188 ± 0.0505 | Propionylglycine-TMS | -0.1330 ± 0.1247 |
Citric acid-d4-4TMS | 0.1073 ± 0.1070 | 4-Hydroxybutyric acid-2TMS | -0.1082 ± 0.1046 |
Rhamnose-4TMS(1) | -0.0966 ± 0.0859 |
Data are the mean ± SEM. VIP means variable importance in projection, which was calculated in OPLS analyses using SIMCA.