Table 5. OPLS analysis of metabolites with variable importance in projection for glomerular cellular component levels.
A. 12 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Glycerol-3TMS | 0.1047 ± 0.1016 | Propionylglycine-TMS | -0.1934 ± 0.1188 |
Linoleic acid-TMS | 0.0832 ± 0.0825 | Fructose-meto-5TMS(1) | -0.1815 ± 0.0557 |
Sorbose-meto-5TMS(1) | -0.1800 ± 0.0665 | ||
Psicose-meto-5TMS(2) | -0.1663 ± 0.0464 | ||
Pantothenic acid-3TMS | -0.1559 ± 0.1047 | ||
Proline-2TMS | -0.1452 ± 0.1035 | ||
B. 22 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Taurine-3TMS | 0.1926 ± 0.0978 | Glyoxylic acid-meto-TMS | -0.0852 ± 0.0604 |
Taurine-13C2-3TMS | 0.1916 ± 0.0998 | ||
Mannose 6-phosphate-meto-6TMS(1) | 0.1806 ± 0.1347 | ||
5-Methoxytryptamine-2TMS | 0.1765 ± 0.0832 | ||
Dihydroorotic acid-3TMS | 0.1732 ± 0.1021 | ||
Spermidine-5TMS | 0.1730 ± 0.1203 | ||
C. 32 weeks | |||
Positive predicting variable | Negative predicting variable | ||
Metabolites | VIP | Metabolites | VIP |
Glycine-2TMS | 0.1230 ± 0.1196 | Cystamine-nTMS | -0.1850 ± 0.1667 |
Dimethylglycine-TMS | 0.1100 ± 0.0883 | 5-Oxoproline-2TMS | -0.1787 ± 0.1074 |
Boric acid-3TMS | 0.1066 ± 0.0842 | Tryptophan-3TMS | -0.1754 ± 0.1232 |
Xylitol-5TMS | 0.0725 ± 0.0449 | Hypoxanthine-2TMS | -0.1650 ± 0.1068 |
Xanthine-3TMS | -0.1329 ± 0.0911 | ||
Rhamnose-4TMS(1) | -0.1312 ± 0.1015 |
Data are the mean ± SEM. VIP means variable importance in projection, which was calculated in OPLS analyses using SIMCA.