Table 6. OPLS analysis of metabolites with variable importance in projection for mesangial substrate levels.
| A. 12 weeks | |||
| Positive predicting variable | Negative predicting variable | ||
| Metabolites | VIP | Metabolites | VIP |
| Coniferyl alcohol-2TMS | 0.0732 ± 0.0513 | Valine-2TMS | -0.1603 ± 0.0520 |
| 3,6-Epoxydodecanedioic acid-2TMS | 0.0627 ± 0.0473 | Leucine-2TMS | -0.1575 ± 0.0317 |
| Methylmalonic acid-2TMS | -0.1571 ± 0.0777 | ||
| Phenylalanine-2TMS | -0.1568 ± 0.0586 | ||
| Glyceraldehyde-meto-2TMS(2) | -0.1560 ± 0.0576 | ||
| Urea-2TMS | -0.1457 ± 0.0701 | ||
| B. 22 weeks | |||
| Positive predicting variable | Negative predicting variable | ||
| Metabolites | VIP | Metabolites | VIP |
| 3-Hydroxyisobutyric acid-2TMS | 0.1410 ± 0.1369 | Stearic acid-TMS | -0.1929 ± 0.0680 |
| Hydroxylamine-3TMS | 0.1092 ± 0.0906 | Margaric acid-TMS | -0.1840 ± 0.1002 |
| Glucono-1,4-lactone-4TMS | -0.1531 ± 0.1254 | ||
| Palmitic acid-TMS | -0.1322 ± 0.0664 | ||
| Glyceraldehyde-meto-2TMS(2) | -0.1282 ± 0.0905 | ||
| Ribitol-5TMS | -0.1255 ± 0.1127 | ||
| C. 32 weeks | |||
| Positive predicting variable | Negative predicting variable | ||
| Metabolites | VIP | Metabolites | VIP |
| Xylitol-5TMS | 0.1185 ± 0.0885 | Tryptophan-3TMS | -0.1663 ± 0.0919 |
| Allose-meto-5TMS(1) | 0.0923 ± 0.0597 | 5-Oxoproline-2TMS | -0.1600 ± 0.1392 |
| Mannose-meto-5TMS(1) | 0.0908 ± 0.0585 | Leucine-2TMS | -0.1346 ± 0.1021 |
| Isoleucine-2TMS | -0.1214 ± 0.0955 | ||
| Ornithine-4TMS | -0.1208 ± 0.1054 | ||
| Ribose-meto-4TMS | -0.1187 ± 0.0834 | ||
Data are the mean ± SEM. VIP means variable importance in projection, which was calculated in OPLS analyses using SIMCA.