Table 2. Protein complexes found in clastic cells and other cell types.
Coatamer protein 1 (COP1) | T-Complex | 20S Proteasome alpha subunits | 20S Proteasome Beta subunits | 26S proteasome Regulatory subunits |
cops8 (U87, Mac) cops7a (MSC, U87, Mac) cops7b (Huh7, MSC, U87) cops5 (Huh7, MSC, U87, Mac) cops6 (U87, Mac) cops3 (Huh7, MSC, U87, Mac) cops4 (Huh7, MSC, U87, Mac) cops2 (Huh7, MSC, U87, Mac) gps1 (Huh7, MSC, U87, Mac) |
CCT2 (Huh7, MSC, U87, Mac) CCT8 (Huh7, MSC, U87, Mac) CCT4 (Huh7, MSC, U87, Mac) CCT6A (Huh7, MSC, U87, Mac) CCT7 (Huh7, MSC, U87, Mac) CCT5 (Huh7, MSC, U87, Mac) CCT3 (Huh7, MSC, U87, Mac) TCP1 (Huh7, MSC, U87, Mac) |
psma2 (Huh7, MSC, U87, Mac) psma6 (Huh7, MSC, U87, Mac) psma4 (Huh7, MSC, U87, Mac) psma3 (Huh7, MSC, U87, Mac) psma1 (Huh7, MSC, U87, Mac) psma7 (Huh7, MSC, U87, Mac) psma5 (Huh7, MSC, U87, Mac) |
psmb2 (Huh7, MSC, U87, Mac) psmb3 (Huh7, MSC, U87, Mac) psmb4 (Huh7, MSC, U87, Mac) psmb1 (Huh7, MSC, U87, Mac) psmb5 (Huh7, MSC, U87, Mac) psmb7 (MSC, U87) psmb6 (Huh7, MSC, U87, Mac) |
psmc6 (Huh7, MSC, U87, Mac) psmc5 (Huh7, MSC, U87, Mac) psmc2 (Huh7, MSC, U87, Mac) psmc3 (Huh7, MSC, U87, Mac) psmc1 (Huh7, MSC, U87, Mac) psmc4 (Huh7, MSC, U87, Mac) |
V-ATPase | 26S proteasome non-ATPase regulatory subunit | V-ATPase subunits not found in clastic cells | 26S proteasome non-ATPase regulatory subunit not found in clastic cells | Arp2/3 complex |
A (Huh7, MSC, U87, Mac) B2 (Huh7, MSC, U87, Mac) E (Huh7, MSC, U87, Mac) H (Huh7, MSC, U87) AC45 (Mac) C (Huh7, MSC, U87, Mac) d2 d1 (Huh7, MSC, U87, Mac) PRR (MSC, U87, Mac) D (Huh7, MSC, U87, Mac) F G (U87) |
psmd10 (MSC, U87, Mac) psmd14 (Huh7, MSC, U87, Mac) psmd7 (Huh7, MSC, U87, Mac) psmd13 (Huh7, MSC, U87, Mac) psmd6 (Huh7, MSC, U87, Mac) psmd11 (Huh7, MSC, U87, Mac) psmd8 (Huh7, MSC, U87, Mac) psmd12 (Huh7, MSC, U87, Mac) psmd5 (Huh7, MSC, U87, Mac) psmd3 (Huh7, MSC, U87, Mac) psmd2 (Huh7, MSC, U87, Mac) psmd1 (Huh7, MSC, U87, Mac) |
a1 (Huh7, MSC, U87, Mac) c (Mac) |
psmd4 (Huh7, MSC, U87, Mac) psmd9 (U87) |
arp3 (Huh7, MSC, U87, Mac) arp2 (Huh7, MSC, U87, Mac) p41 (Huh7, MSC, U87, Mac) p34 (Huh7, MSC, U87, Mac) p21 (Huh7, MSC, U87, Mac) p20 (Huh7, MSC, U87, Mac) p19 (Huh7, MSC, U87, Mac) |
Parentheses after gene symbol indicates cell types where found: human monocyte-derived macrophages (Mac), U87 glioblastoma cells (U87), Huh7 hepatocellular carcinoma cells (Huh7) and human bone marrow-derived mesenchymal stem cells (MSC). Gene symbol in normal font indicates it is present in clasts, osteoclasts and odontoclasts. Gene symbol in bold indicates it is found in osteoclast and odontoclasts, but not clasts. Gene symbol underlined means it is found only in osteoclasts. Data from Huh7, MSC, U87 and Mac come from references [27,28].