Table 1. Characterization of inbred strains for naturally occurring hematopoietic neoplasms.
Disease Incidence, Latency, Typea | Strain | Emvs | X/P-ERVs Involved in P-MLV Generationd | Fv1 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locusb | Expressionc | Pmvs | Xmvs | ||||||||||
High, Early, T Cell | AKR | Emv11-14 | SpH | 13 | 20 | 10 | Bxv1 | n | |||||
C58 | 4–6 Emvs | SpH | 1 | 11 | 13 | 20 | 10 | Bxv1 | n | ||||
HRS | Emv1,3 | SpH | 1 | 11 | 13 | 15 | 20 | Bxv1 | n | ||||
P | Emv3 | NT | 1 | 20 | 10 | 13 | n | ||||||
PL | 3–4 Emvs | NT | 1 | 13 | 20 | n | |||||||
SAMP7 | Emv11+1Emv | SpH | 1 | 13 | Bxv1 | n | |||||||
SAMP8 | Emv11+7Emvs | SpH | 1 | 13 | Bxv1 | n | |||||||
SAMP9 | Emv11+2Emvs | SpH | 1 | 13 | 20 | n | |||||||
Moderate, Late, Low, T Cell or Non-T Cell | C3H | Emv1 | Ind | 1 | 13 | 15 | 20 | IV1 | n | ||||
C57BR | Emv2 | NT | 1 | 11 | 13 | 20 | 10 | Bxv1 | IV1 | n | |||
CBA/J | Emv1 | Ag+ | 1 | 13 | 15 | 20 | 13 | IV1 | n | ||||
MA/My | Emv8,9 | (Ind),Ag+ | 1 | 20 | Bxv1 | n | |||||||
NOD | Emv30 | SpL | 1 | 13 | 20 | n | |||||||
SAMP1 | Emv11+2Emvs | SpH | 1 | 13 | n | ||||||||
SAMP10 | Emv11+5Emvs | SpH | 1 | 13 | 10 | n | |||||||
SAMR5 | 3Emvs | - | 1 | 13 | 20 | n | |||||||
SEA | Emv1,3 | SpL,Ind | 1 | 11 | 13 | 20 | n | ||||||
SJL | Emv9,10 | SpL,Ind,Ag+ | 1 | 13 | n | ||||||||
NON | Emv30 | SpL | 1 | 13 | 20 | n | |||||||
SAMP6 | 2Emvs | - | 1 | 13 | 10 | n | |||||||
SAMP11 | Emv11 | SpH | 1 | 13 | 20 | n | |||||||
SAMR1 | 2Emvs | SpL | 1 | 13 | 20 | n | |||||||
SAMR4 | 2Emvs | SpL | 1 | 13 | 20 | n | |||||||
F/St | Emv+ | SpH | 13 | 10 | Bxv1 | nr | |||||||
LP | Emv5 | NT | 1 | 11 | 13 | nr | |||||||
KK | Emv+ | NT | 1 | 15 | 20 | nr | |||||||
NZW | Emv+ | NT | 1 | 11 | 13 | 20 | nr | ||||||
RF | Emv1,2 | Ag+ | 1 | 13 | 20 | 10 | nr | ||||||
SM | Emv1 | NT | 1 | 11 | 13 | 20 | nr | ||||||
DBA/2 | Emv3 | SpL | 1 | 13 | 20 | 10 | Bxv1 | d | |||||
NZO | Emv+ | NT | 1 | 11 | 13 | 20 | d | ||||||
A | Emv1 | Ind,Ag+ | 1 | 13 | 20 | 10 | IV1 | b | |||||
BALB/c | Emv1 | Ind,Ag+ | 1 | 11 | 13 | 20 | Bxv1 | b | |||||
C57BL | Emv2 | (Ind) | 1 | 11 | 13 | 15 | 20 | 10 | Bxv1 | IV1 | b | ||
I | Emv1,3 | Ag- | 1 | 11 | 13 | 20 | 10 | 13 | Bxv1 | IV1 | b | ||
YBR | Emv+ | NT | 1 | 11 | 13 | 20 | 10 | b |
bMany Emvs have assigned numbers [6, 46]; Emv+, strains carrying uncharacterized PCR-detected Emv env sequences.
cExpression is identified as: SpH, spontaneous high; SpL, spontaneous low; Ag+, viral antigen positive; Ind, inducible by iododeoxyuridine; -, no expression; NT, not tested.
dThe X/P-MLV ERVs that contribute to P-MLVs were previously identified [13].