Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 9;18(14):1601–1618. doi: 10.1080/15384101.2019.1624112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Informa UK Limited, trading as Taylor & Francis Group

PMC Copyright notice

Figure 2. — The correlation analyses between KIF23 and cell cycle-related proteins.

A: Using the STRING online database, total of 717 DEGs were filtered into the DEGs protein–protein interaction (PPI) network complex. PPI network modules were screened by Molecular Complex Detection (MCODE) plug-in. The most significantly functional module in the protein–protein interaction network was showed; B: Enrichment of signaling pathways of DEGs conducted in the module; C: The PPI network of KIF23 and cell cycle-related genes (BUB1, BUB1B, CCNB1, CCNB2, CDK1, MCM2, PTTG1 and TTK); D: The correlation analyses from GEPIA between KIF23 and cell cycle-related genes. Significant correlations were observed between KIF23 mRNA expression and mRNA expression of BUB1 (R = 0.72, P < 0.001), BUB1B (R = 0.74, P < 0.001), CCNB1 (R = 0.59, P < 0.001), CCNB2 (R = 0.81, P < 0.001), CDK1 (R = 0.66, P < 0.001), MCM2 (R = 0.52, P < 0.001), PTTG1 (R = 0.42, P < 0.001), TTK (R = 0.63, P < 0.001) (R: Pearson Correlation Coefficient); E: The expression of KIF23 mRNA is positively correlated with the expression of Ki67 mRNA analysed by GEPIA in ovarian serous cystadenocarcinoma tissues from TCGA (R = 0.67, P < 0.001); F: GSEA indicating KEGG CELL CYCLE signatures pathways was more correlated with patients with KIF23 high versus KIF23 low patients (FDR: False Discovery Rate).