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. Author manuscript; available in PMC: 2019 Jul 10.
Published in final edited form as: Comb Chem High Throughput Screen. 2009 Mar;12(3):285–295. doi: 10.2174/138620709787581738

Fig. (5).

Fig. (5)

(A) A titration mixture of ibuprofen, cinoxacin, L-proline (Pro), and adenosine 5’-triphosphate disodium salt (ATP) with increasing concentrations (i) 0 μM, (ii) 0.4 μM, (iii) 1.0 μM, and (iv) 3.0 μM of HSA. (B) Only ibuprofen binds HSA and the decrease in peak intensity describes the binding curve from eq 1. The resulting equilibrium dissociation constant (KD) for ibuprofen was 0.46 ± 0.8 μM with a NMR line width ratio constant (c) of 31.8.