Figure 2. Task-related neural activation and task-related cortical networks.

(A) Significant task-induced activations (red) and deactivations (blue) that correlate with increasing working memory load, showing increased activation within dorsolateral prefrontal cortex and parietal cortex, and decreased activation within ventromedial prefrontal cortex, posterior cingulate cortex and medial temporal lobe. Activation and deactivation maps thresholded at whole-brain cluster threshold (cluster-level family-wise error corrected P < 0.05), and displayed in coronal, sagittal and axial sections overlaid on a single-subject normalized T1 image in MNI space (see Table 1 for statistical results). (B) Lateral (top) and top-down (bottom) rendering illustrating nodes of the empirical task-positive (TPN, in red) and default mode (DMN, in blue) networks identified by the community detection algorithm.