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. 2019 Jun 24;157(4):304–311. doi: 10.1111/imm.13084

Figure 4.

Figure 4

Expression of Ras‐GTPases in CD4+ T cells from patients with chronic obstructive pulmonary disease‐associated pulmonary hypertension (COPD‐PH) and controls. (a) The expression of KRAS, NRAS, and HRAS in CD4+ T cells ex vivo. (b) The expression of KRAS, NRAS and HRAS in CD4+ T cells upon CD3/CD28 activation. (c) The RORC3/FOXP3 ratio in High‐KRAS and Low‐KRAS controls (filled) and patients (open). (d) The RORC3/FOXP3 ratio in High‐NRAS and Low‐NRAS controls (filled) and patients (open). (e) The expression of KRAS, NRAS and HRAS in control CD4+ T cells upon CD3/CD28 activation and exogenous interleukin (IL‐6). (f) The expression of KRAS, NRAS and HRAS in patient CD4+ T cells upon CD3/CD28 activation and exogenous IL‐6. Unpaired t‐test with Welch's correction.