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. 2019 Jun 24;157(4):304–311. doi: 10.1111/imm.13084

Figure 5.

Figure 5

Inhibition of Ras‐GTPases on the ratio of RORC2/FOXP3 expression. (a) The RORC3/FOXP3 ratio in healthy controls and patients with chronic obstructive pulmonary disease‐associated pulmonary hypertension (COPD‐PH) upon CD3/CD28 activation and farnesylthiosalicylic acid (FTS) treatment. Repeated measures one‐way analysis of varaince followed by Dunnett's multiple comparison tests. (b) Interleukin‐17 (IL‐17) secretion in healthy controls and COPD‐PH patients upon CD3/CD28 activation and FTS treatment. (c) Transforming growth factor‐β (TGF‐β) secretion in healthy controls and COPD‐PH patients upon CD3/CD28 activation and FTS treatment. Paired t‐test.