Table 3.

Putative targets with approved drugs common to all Tier 2 metabolic network models of P. aeruginosa. Targets marked with asterisks are also associated with drugs in the experimental stage. Drugs marked with double asterisks are most probably artifacts inherited from DrugBank.

EC number	Gene name	Approved drug
1.3.1.98	murB*	Flavin adenine dinucleotide**
1.5.1.3	folA*	Levoleucovorin
1.5.1.3	folA*	Isoniazid
2.3.1.41	fabB*	Cerulenin
2.5.1.15	folP	Sulfacytine
2.5.1.15	folP	Sulfaphenazole
2.5.1.15	folP	Sulfamethoxazole
2.5.1.15	folP	Sulfanilamide
2.5.1.15	folP	Sulfacetamide
2.5.1.15	folP	Sulfamethazine
2.5.1.15	folP	Sulfamethizole
2.5.1.15	folP	Sulfisoxazole
2.5.1.15	folP	Sulfamerazine
2.5.1.7	murA*	Fosfomycin
2.6.1.85	pabB	Formic acid**
4.2.1.24	hemB*	Formic acid**
4.2.3.5	aroC	Riboflavin monophosphate**
5.3.1.6	rpiA*	Citric acid**

The EC (enzyme commission) numbers represent the classification of P. aeruginosa enzymes according to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB).Gene and associated drug names were retrieved from UniProt and DrugBank databases, respectively.