Table 4.

List of EC numbers, product, and DrugBank inhibitor status for putative targets for metabolic network models of K. pneumoniae and H. influenzae. All targets listed in this table are included in the results of both FBA+FVA and FBA-only methods.

EC number	Gene name	Product	DrugBank inhibitor	Species
1.3.1.98	murB	UDP-N-acetylenolpyruvoylglucosamine reductase	A/E	K. pneumoniae
2.3.1.117	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	E	K. pneumoniae
2.3.1.129	lpxA	Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	E	K. pneumoniae
2.3.1.179	fabF	3-oxoacyl-[acyl-carrier-protein] synthase 2	A/E	K. pneumoniae
2.3.1.41	fabB	3-oxoacyl-[acyl-carrier-protein] synthase 1	A/E	K. pneumoniae
2.7.2.8	argB	Acetylglutamate kinase	E	K. pneumoniae
2.7.4.9	tmk	Thymidylate kinase	E	K. pneumoniae
4.2.1.59	fabA	3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	E	K. pneumoniae
6.3.2.13	murE	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	E	K. pneumoniae
6.3.2.8	murC	UDP-N-acetylmuramate–L-alanine ligase	E	K. pneumoniae
6.3.2.9	murD	UDP-N-acetylmuramoylalanine–D-glutamate ligase	E	K. pneumoniae
1.5.1.3	folA	Dihydrofolate reductase	A/E	H. influenzae
2.7.4.9	tmk	Thymidylate kinase	E	H. influenzae
2.7.7.38	kdsB	3-deoxy-manno-octulosonate cytidylyltransferase	E	H. influenzae
6.1.1.10	metG	Methionine–tRNA ligase	E	H. influenzae
6.1.1.2	trpS	Tryptophan–tRNA ligase	A/E	H. influenzae
6.1.1.21	hisS	Histidine–tRNA ligase	E	H. influenzae
6.1.1.3	thrS	Threonine–tRNA ligase	E	H. influenzae
6.3.5.2	guaA	GMP synthase [glutamine-hydrolyzing]	A	H. influenzae

The EC (Enzyme Commission) numbers represent the classification of K. pneumoniae and H. influenzae enzymes according to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB). Gene, product, and DrugBank Inhibitor Status were retrieved from UniProt and DrugBank databases, respectively. Abbreviations: experimental (E) and approved (A).