Table 2.
Analysis of EQ-5D-5L index score, Tobit model with repeated measures results
| Without VTE/bleeding events (n = 1191, Obs = 4024) | With VTE/bleeding events (n = 1191, Obs = 3875) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coef. | Std. Err. | p > z | [95% Conf. | Interval] | Coef. | Std. Err. | p > z | [95% Conf. | Interval] | |
| Patients without ACTIVE cancer | ||||||||||
| Constant | 0.974 | 0.044 | < 0.001 | 0.888 | 1.060 | 0.970 | 0.044 | < 0.001 | 0.884 | 1.057 |
| Age | − 0.001 | 0.000 | 0.006 | − 0.002 | 0.000 | − 0.001 | 0.000 | 0.011 | − 0.002 | 0.000 |
| Male | 0.105 | 0.013 | < 0.001 | 0.079 | 0.131 | 0.105 | 0.013 | < 0.001 | 0.079 | 0.131 |
| Body mass index | − 0.004 | 0.001 | 0.001 | − 0.006 | − 0.002 | − 0.004 | 0.001 | 0.001 | − 0.006 | − 0.002 |
| Previous stroke | − 0.115 | 0.040 | 0.004 | − 0.192 | − 0.037 | − 0.120 | 0.040 | 0.003 | − 0.199 | − 0.042 |
| Prolong immobilization | − 0.074 | 0.021 | < 0.001 | − 0.114 | − 0.034 | − 0.072 | 0.021 | 0.001 | − 0.112 | − 0.031 |
| > 5 day in bed | − 0.071 | 0.024 | 0.003 | − 0.118 | − 0.023 | − 0.068 | 0.024 | 0.005 | − 0.116 | − 0.021 |
| Varicose veins | 0.036 | 0.017 | 0.037 | 0.002 | 0.070 | 0.038 | 0.017 | 0.03 | 0.004 | 0.072 |
| Vascular disease | − 0.092 | 0.027 | 0.001 | − 0.145 | − 0.039 | − 0.090 | 0.027 | 0.001 | − 0.143 | − 0.036 |
| Dyslipidemia | 0.040 | 0.015 | 0.010 | 0.010 | 0.070 | 0.038 | 0.015 | 0.014 | 0.008 | 0.068 |
| Diabetes mellitus | − 0.059 | 0.022 | 0.007 | − 0.101 | − 0.016 | − 0.055 | 0.022 | 0.011 | − 0.098 | − 0.013 |
| Chronic respiratory disease | − 0.057 | 0.022 | 0.009 | − 0.100 | − 0.015 | − 0.059 | 0.022 | 0.007 | − 0.102 | − 0.016 |
| Arthritis | − 0.068 | 0.026 | 0.008 | − 0.119 | − 0.018 | − 0.065 | 0.026 | 0.013 | − 0.116 | − 0.014 |
| Bone fracture/soft tissue trauma | − 0.073 | 0.022 | 0.001 | − 0.116 | − 0.030 | − 0.074 | 0.022 | 0.001 | − 0.117 | − 0.031 |
| VTE event during follow-up | Not included | − 0.061 | 0.043 | 0.158 | − 0.145 | 0.024 | ||||
| Bleeding event during follow-up | Not included | − 0.050 | 0.022 | 0.027 | − 0.094 | − 0.006 | ||||
| Without VTE/bleeding events (n = 110, Obs = 321) | With VTE/bleeding events (n = 110, Obs = 296) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coef. | Std. Err. | p > z | [95% Conf. | Interval] | Coef. | Std. Err. | p > z | [95% Conf. | Interval] | |
| Patients with ACTIVE cancer | ||||||||||
| Constant | 1.236 | 0.161 | < 0.001 | 0.921 | 1.552 | 1.237 | 0.165 | 0 < 0.001 | 0.914 | 1.560 |
| Age | − 0.008 | 0.002 | 0.001 | − 0.012 | − 0.003 | − 0.008 | 0.002 | 0.001 | − 0.013 | − 0.003 |
| Previous stroke | − 0.762 | 0.313 | 0.015 | − 1.376 | − 0.148 | − 0.758 | 0.318 | 0.017 | − 1.382 | − 0.134 |
| VTE event during follow-up | Not included | 0.069 | 0.182 | 0.704 | − 0.288 | 0.427 | ||||
| Bleeding event during follow-up | Not included | − 0.076 | 0.091 | 0.400 | − 0.254 | 0.102 | ||||
N number of patients, Obs. number of observations of index scores (per patient could contribute multiple, up to 5, observations), VTE venous thromboembolism
The full list of covariate set includes age, gender, BMI, clinical factors (previous VTE event, PE with DVT), previous clinical events (within 3 years prior to enrollment: myocardial infarction, coronary heart disease, percutaneous coronary intervention, atrial fibrillation, transient ischemic attack, stroke, and bleeding event), risk factors (within the past 3 months or ongoing: prolonged immobilization (> 5 days in bed), varicose veins, history of major surgery or trauma), comorbidities (hypertension, congestive heart failure, vascular disease, dyslipidemia, diabetes, chronic venous insufficiency, renal disease, liver disease, chronic respiratory disease, arthritis, bone fracture/soft tissue trauma, lower extremity paralysis, alcohol use, smoking history, and thrombophilia), and VTE/bleeding events during follow-up