Table 4.

Analysis of mortality, logistic regression results adjusted for significant baseline variables

	Baseline characteristics (n = 1183)					Baseline characteristics (excluding PE Symptomsa) and EQ-5D-5L index score (n = 1198)
	Odds ratio	Std. err.	p value	[95% conf.	Interval]	Odds ratio	Std. err.	p value	[95% conf.	Interval]
Total PE cohort
Constant	0.017	0.018	< 0.001	0.002	0.135	0.201	0.231	0.162	0.021	1.912
Age	1.046	0.011	< 0.001	1.025	1.068	1.043	0.011	< 0.001	1.022	1.065
BMI	0.905	0.025	< 0.001	0.857	0.955	0.887	0.026	< 0.001	0.837	0.939
Active cancer	13.137	3.600	< 0.001	7.678	22.478	12.348	3.495	< 0.001	7.090	21.504
Prolong immobilization	2.587	0.777	0.002	1.436	4.661
Vascular disease	2.361	0.789	0.010	1.226	4.545
Previous AF	2.531	1.007	0.020	1.16	5.52	2.871	1.159	0.009	1.301	6.334
Smoking history	1.931	0.495	0.010	1.168	3.191	1.967	0.534	0.013	1.155	3.349
Palpitations	2.276	0.874	0.032	1.072	4.831	Not includeda
EQ-5D-5L index score at baseline	Not included					0.095	0.040	< 0.001

	Baseline characteristics (n = 1071)					Baseline characteristics (excluding PE Symptomsa) and EQ-5D-5L index score (n = 1090)
	Odds ratio	Std. err.	p value	[95% conf.	Interval]	Odds ratio	Std. err.	p value	[95% conf.	Interval]
Patients without ACTIVE cancer
Constant	0.194	0.280	0.257	0.011	3.294	0.502	0.775	0.655	0.024	10.315
Age	1.058	0.014	< 0.001	1.030	1.086	1.054	0.014	< 0.001	1.027	1.082
Body mass index	0.796	0.035	< 0.001	0.730	0.869	0.808	0.035	< 0.001	0.742	0.881
Prolong immobilization	2.570	0.866	0.005	1.328	4.975	2.053	0.737	0.045	1.016	4.148
Vascular disease	3.580	1.353	0.001	1.707	7.510	2.493	1.014	0.025	1.124	5.531
Diabetes mellitus	2.575	0.985	0.013	1.217	5.448	2.534	0.996	0.018	1.173	5.474
Cardiogenic shock	17.573	11.213	< 0.001	5.032	61.373	Not includeda
EQ-5D-5L index score at baseline	Not included					0.220	0.117	0.004	0.078	0.622

	Baseline characteristics (n = 112)					Baseline characteristics (excluding PE Symptomsa) and EQ-5D-5L index score (n = 108)
	Odds ratio	Std. err.	p value	[95% conf.	Interval]	Odds ratio	Std. err.	p value	[95% conf.	Interval]
Patients with ACTIVE cancer
Constant	0.311	0.101	< 0.001	0.164	0.588	3.232	1.934	0.050	1.001	10.440
Smoking history	2.964	1.246	0.010	1.300	6.758	3.346	1.514	0.008	1.379	8.122
Tachycardia	6.295	3.633	0.001	2.031	19.510	Not includeda
EQ-5D-5L index score at baseline	Not included					0.035	0.031	< 0.001	0.006	0.193

The full list of covariate set includes age, gender, BMI, clinical factors (previous VTE event, PE with DVT), previous clinical events (within 3 years prior to enrollment: myocardial infarction, coronary heart disease, percutaneous coronary intervention, atrial fibrillation, transient ischemic attack, stroke, and bleeding event), risk factors (within the past 3 months or ongoing: active cancer, prolonged immobilization (> 5 days in bed), varicose veins, history of major surgery or trauma), comorbidities (hypertension, congestive heart failure, vascular disease, dyslipidemia, diabetes, chronic venous insufficiency, renal disease, liver disease, chronic respiratory disease, arthritis, bone fracture/soft tissue trauma, lower extremity paralysis, alcohol use, smoking history, and thrombophilia), the presence of PE symptoms, and EQ-5D-5L index score at baseline

PE pulmonary embolism

^aBaseline PE symptoms were not considered in this model (i.e., Dyspnea, Chest pain, Cough, Hemoptysis, Syncope, Palpitations, Fever, Cyanosis, Tachypnea, Tachycardia, Cardiogenic shock, Others.)