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. 2019 Jul 10;10:3031. doi: 10.1038/s41467-019-10703-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Reduced number of fetal Treg cells and fetal Treg thymic output in preeclampsia. Nepean cohort 3: a Scatter dot plot showing Treg cell frequencies in term maternal-fetal dyads in both non-preeclamptic (non-PE) (n = 62, black dots) and preeclamptic (PE) pregnancies (n = 26, red dots). Pearson’s correlation was used. Coefficient r and p-values as indicated. b Scattered dot plots comparing the %Foxp3⁺ (Mean) within CD4⁺ cells in cord blood (n = 66 for non-PE, n = 29 for PE group) and maternal blood (n = 62 for non-PE group, n = 27 for PE group) (unpaired t-test). Gating strategy for Foxp3⁺ Tregs from PBMC is shown in Supplementary Fig. 2. c Representative dot plot showing cord blood Foxp3⁺Helios⁺ cells gated on CD4⁺ cells. d Scattered dot plots showing the percentage of Foxp3⁺Helios⁺ cells (Mean) in cord blood. Left panel comparing %Foxp3⁺Helios⁺ cells in non-PE (n = 20) and PE (n = 19) groups (unpaired t-test). Right panel dividing the PE group into two subgroups based on steroids treatment: n = 10 for no Steroids and n = 9 for plus Steroids (one-way ANOVA with Dunnett’s multiple comparisons test). *p < 0.05, **p < 0.01