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. 2019 Jul 10;10:3031. doi: 10.1038/s41467-019-10703-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Reduced Foxp3 MFI in thymic Treg cells from GF pups recovered with acetate supplementation. Three-week-old C57BL/6 pups from control SPF and GF mothers and GF mothers treated with acetate in drinking water (ADW). Cumulative data showing phenotypic analysis by flow cytometry in the thymus from pooled female and male pups (n = 7–10/group). a Thymus weight. b Thymocyte cellularity per thymic lobe. c Bone marrow cellularity. d The frequency of bone marrow CD62L⁺ lymphoid-primed multipotent progenitor (LMPP) cells. e The total number of CD4SP cells. f The total number of CD4SP Foxp3⁺ cells. g Foxp3 protein expression on a per cell basis in thymic CD4SP Foxp3⁺ cells. Gating strategies for LMPP cells, CD4SP cells and Foxp3⁺ cells are shown in Supplementary Figs. 3 and 4. The data are shown as mean fluorescence intensity (MFI). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. All data were analyzed by one-way ANOVA with Bonferroni’s multiple comparisons test. Data represent mean; each symbol represents an individual mouse. Data are representative of at least two independent experiments