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. 2019 Jul 10;9:10004. doi: 10.1038/s41598-019-46473-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the correlation between the gene expression in the T helper cell type 1/2 (Th-1/Th-2) status and immune checkpoint in primary central nervous system lymphoma (PCNSL). (a) Correlation among Th-1 (red) and Th-2 (green), stimulatory checkpoint (blue), and inhibitory checkpoint (purple). (b) Correlation among inhibitory checkpoint molecules. Thick and thin lines with a distance indicate strong and weak correlation between the expression levels of the two genes. The numbers with circles indicate the numbers of nodes over two.