Table 3.
The target pathway candidates in PCNSL.
| Pathway | Pathway name | KEGG PathGenes | Chip PathGenes | Target AllGenes | Target PathGenes | P Value |
|---|---|---|---|---|---|---|
| (Gene) | ||||||
| hsa04024 | cAMP signaling pathway - Homo sapiens (human) | 212 | 211 | 361 | 24 | 0.00041 |
| hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) | 338 | 337 | 361 | 31 | 0.00153 |
| hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) | 492 | 489 | 361 | 9 | 0.00214 |
| hsa04062 | Chemokine signaling pathway - Homo sapiens (human) | 190 | 187 | 361 | 18 | 0.0103 |
| hsa05020 | Prion diseases - Homo sapiens (human) | 35 | 35 | 361 | 6 | 0.01052 |
| hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) | 178 | 175 | 361 | 2 | 0.02537 |
| hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) | 144 | 140 | 361 | 13 | 0.03052 |
| hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) | 201 | 199 | 361 | 3 | 0.03652 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) | 51 | 51 | 361 | 6 | 0.04576 |
| hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) | 91 | 90 | 361 | 9 | 0.04751 |
| (Isoform) | ||||||
| hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) | 338 | 337 | 3140 | 59 | 0.00001 |
| hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) | 294 | 293 | 3140 | 74 | 0.00011 |
| hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) | 219 | 219 | 3140 | 139 | 0.00016 |
| hsa05010 | Alzheimer disease - Homo sapiens (human) | 171 | 152 | 3140 | 104 | 0.00017 |
| hsa04218 | Cellular senescence - Homo sapiens (human) | 160 | 157 | 3140 | 101 | 0.00089 |
| hsa04110 | Cell cycle - Homo sapiens (human) | 124 | 124 | 3140 | 82 | 0.00152 |
| hsa05034 | Alcoholism - Homo sapiens (human) | 180 | 180 | 3140 | 111 | 0.00172 |
| hsa04144 | Endocytosis - Homo sapiens (human) | 244 | 233 | 3140 | 136 | 0.0025 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) | 149 | 143 | 3140 | 89 | 0.00355 |
| hsa03050 | Proteasome - Homo sapiens (human) | 45 | 44 | 3140 | 35 | 0.00597 |
| hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) | 212 | 205 | 3140 | 118 | 0.00637 |
| hsa04210 | Apoptosis - Homo sapiens (human) | 136 | 134 | 3140 | 81 | 0.01005 |
| hsa05211 | Renal cell carcinoma - Homo sapiens (human) | 69 | 65 | 3140 | 44 | 0.01483 |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) | 186 | 184 | 3140 | 103 | 0.01815 |
| hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) | 101 | 99 | 3140 | 60 | 0.02279 |
| hsa05164 | Influenza A - Homo sapiens (human) | 171 | 170 | 3140 | 92 | 0.04659 |