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. 2019 Jul 10;9:9968. doi: 10.1038/s41598-019-46355-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Integrative analysis of DNA copy number and expression variation in SALS patients reveals a good number of overlapping ALS candidate genes. (a) Graphical overview of the most frequent (≥10%) CNV-embedded genes detected in SALS patients, both with and without the assignment into the hierarchically determined two sets (SALS1 and SALS2). (b,c) Venn diagrams compare the number of protein-coding genes obtained from CNV analyses with the genes found to be differentially expressed in SALS1 (b) and SALS2 (c) patients.