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. 2019 Jul 10;9:9968. doi: 10.1038/s41598-019-46355-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional enrichment analysis for GO and pathway map ontologies revealed significant biological processes associated with the candidate CNV-driven genes in SALS. (a) Pie charts represent the top 10 enriched (P < 0.05) GO terms for the 70 CNV-encompassed DEGs in SALS1 and SALS2 patients. The GO terms were subdivided into three GO categories: biological processes, molecular functions and cellular components. Enrichment analyses were performed using the Enrichment Analysis tool in Enrichr. For each category, GO terms or biological features represented in CNV-driven differently expressed genes are indicated. (b) Representation of the top 20 most significantly enriched (P value < 0.05) canonical pathway maps associated with the candidate CNV-driven genes in SALS1 and SALS2 patients. A histogram of statistical significance (−log P value) is shown: the list is arranged in descending order with the most significant pathways at the top. The analysis was performed using the MetaCore™ pathway analysis suite.