Fig. 2.

PSEVs contain phenotypic and genotypic information. a BMI cohort versus Disease rank. The top fourranked Diseases in the in cohort IV’s PSEV were obesity, hypertension, type 2 diabetes mellitus, and metabolic syndrome X. All four show a positive relationship with BMI. The opposite trend was observed for celiac disease, Crohn’s disease, and attention-deficit disorder which were highly ranked in cohort I’s PSEV. b FTO gene was positively correlated with BMI. c The number of overlapping genes between the GWAS catalog for increased BMI (n = 365) and the top 365 Genes in each BMI cohort PSEV