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. 2019 Jul 10;10:3043. doi: 10.1038/s41467-019-11039-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Disease risk in offspring of older fathers vs. offspring of younger fathers in dnSNV model and Danish population. SCZ schizophrenia, ASD autism spectrum disorder, CHD congenital heart disease, EPI neurodevelopmental disorders with epilepsy, ID intellectual disability. Error bars reflect 95% confidence intervals. *p < 2 × 10⁻⁴ against null hypothesis that epidemiologic association between advanced paternal age and disease risk is equivalent to the dnSNV model’s estimate (empiric p value as described in Methods)