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. 2019 Jul 10;9:10007. doi: 10.1038/s41598-019-46316-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of MenSCs decidualization on cytotoxicity of NK cells. (A) MenSCs were in vitro decidualized in the presence or absence of IFN-γ, and (B) the expression of PRL and IGFBP-1 was assessed by real-time RT-PCR in comparison to control cells. (C) Effect of MenSCs decidualized in the absence of IFN-γ on CD16 expression in NK cells was investigated after 2 days co-culture by flow cytometry. dMenSCs significantly (P < 0.01) reduced percent of CD16 expression in CD56 + NK cells. (dMenSCs: 31.06% ± 1.38, UndMenSCs: 35.73% ± 1.35 and NK only: 31.85% ± 1.95) (D) MenSCs decidualized in the presence of IFN-γ had no significant effect on CD16 expression in comparison to NK cells cultured alone (NK only), but (E) significantly reduced NK cytotoxicity against K562 cells at all ratios. P values less than 0.05, 0.01, 0.001, and 0.0001 are shown with *, **, *** and, **** respectively. Images were photographed by an Olympus microscope (BX-51) equipped with a CCD camera (DP71) camera. UndMenSCs: Undifferentiated MenSCs, dMenSCs: decidulized MenSCs.