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. 2019 Jul 5;25:359–372.

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Copyright © 2019 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Minocycline attenuates LPS-induced retinal inflammation via suppression of microglia activation. A: Immunofluorescent staining of retinal whole-mounts show iba-1 (red) at 3 h post-infection, and interleukin-1 beta (IL-1β; green) and chemokine (C-C motif) ligand 2 (CCL-2; green) at 24 h in the lipopolysaccharide (LPS) stimulation with or without minocycline treatment eyes (n=4 per group). Scale bar: 40 μm. B: Real-time PCR analysis of the mRNA expression of tumor necrosis factor-α (TNF-α), CCL-2, IL-1β, and IL-6 in LPS stimulation with or without minocycline treatment eyes at 24 h post-infection. *p<0.05 compared with the LPS treated with PBS group.